BP401T Pharmaceutical Organic Chemistry -III Notes B Pharm 4th Semester
This subject imparts knowledge on stereo-chemical aspects of organic compounds and organic reactions, important named reactions, chemistry of important hetero cyclic compounds. It also emphasizes on medicinal and other uses of organic compounds.
Objectives: At the end of the course, the student shall be able to
- understand the methods of preparation and properties of organic compounds
- explain the stereo chemical aspects of organic compounds and stereo chemical reactions
- know the medicinal uses and other applications of organic compounds
A. Optical isomerism
- Optical activity, enantiomerism, diastereoisomerism, meso compounds
- Elements of symmetry, chiral and achiral molecules
- DL system of nomenclature of optical isomers, sequence rules, RS system of nomenclature of optical isomers
- Reactions of chiral molecules
- Racemic modification and resolution of racemic mixture.
- Asymmetric synthesis: partial and absolute
B. Geometrical isomerism
- Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems)
- Methods of determination of configuration of geometrical isomers.
C. Conformational isomerism in Ethane, n-Butane and Cyclohexane.
D. Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical activity. e. Stereospecific and stereoselective reactions
- Nomenclature and classification
- Synthesis, reactions and medicinal uses of following compounds/derivatives Pyrrole, Furan, and Thiophene – Relative aromaticity, reactivity and Basicity of pyrrole
- Synthesis, reactions and medicinal uses of following compounds/derivatives
- Pyrazole, Imidazole, Oxazole and Thiazole.
- Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine d. Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives
- Reactions of synthetic importance
- Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction.
- Oppenauer-oxidation and Dakin reaction.
- Beckmanns rearrangement and Schmidt rearrangement.
- Claisen-Schmidt condensation
Recommended Books (Latest Editions)
- Organic chemistry by I.L. Finar, Volume-I & II.
- A text book of organic chemistry – Arun Bahl, B.S. Bahl.
- Heterocyclic Chemistry by Raj K. Bansal
- Organic Chemistry by Morrison and Boyd
- Heterocyclic Chemistry by T.L. Gilchrist