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    HomePharmacy coursesB.PharmB Pharmacy 4th semester Organic Chemistry pdf notes

    B Pharmacy 4th semester Organic Chemistry pdf notes

    BP401T Pharmaceutical Organic Chemistry -III Notes B

    Pharm 4th Semester

    B.PharmacyOrganic Chemistry / BPharm 4th Sem Notes

    This subject imparts knowledge on stereochemical aspects of organic compounds and organic reactions, important named reactions, the chemistry of important heterocyclic compounds. It also emphasizes medicinal and other uses of organic compounds.

    Optical Isomerism, Unit-I, BPharm 4th semester ( Vikas Shukla) (1).pdfDownload

    Objectives: At the end of the course, the student shall be able to

    1. understand the methods of preparation and properties of organic compounds
    2. explain the stereochemical aspects of organic compounds and stereochemical reactions
    3. know the medicinal uses and other applications of organic compounds

    Course Content:

    UNIT-I
    Stereoisomerism

    A. Optical isomerism

    • Optical activity, enantiomerism, diastereoisomerism, meso compounds
    • Elements of symmetry, chiral and achiral molecules
    • DL system of nomenclature of optical isomers, sequence rules, the RS system of nomenclature of optical isomers
    • Reactions of chiral molecules
    • Racemic modification and resolution of a racemic mixture.
    • Asymmetric synthesis: partial and absolute

    UNIT-II

    B. Geometrical isomerism

    • Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems)
    • Methods of determination of the configuration of geometrical isomers.

    C. Conformational isomerism in Ethane, n-Butane, and Cyclohexane.

    D. Stereoisomerism in biphenyl compounds (Atropisomerism) and conditions for optical activity. e. Stereospecific and stereoselective reactions

    UNIT-III

    Heterocyclic compounds:

    • Nomenclature and classification
    • Synthesis, reactions, and medicinal uses of following compounds/derivatives Pyrrole, Furan, and Thiophene – Relative aromaticity, reactivity, and Basicity of pyrrole

    UNIT-IV

    • Synthesis, reactions, and medicinal uses of the following compounds/derivatives
    • Pyrazole, Imidazole, Oxazole, and Thiazole.
    • Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine d. Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives

    UNIT-V

    • Reactions of synthetic importance
      • Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction.
      • Oppenauer-oxidation and Dakin reaction.
      • Beckmann’s rearrangement and Schmidt rearrangement.
      • Claisen-Schmidt condensation

    Recommended Books (Latest Editions)

    1. Organic chemistry by I.L. Finisar, Volume-I & II.
    2. A textbook of organic chemistry – Arun Bahl, B.S. Bahl.
    3. Heterocyclic Chemistry by Raj K. Bansal
    4. Organic Chemistry by Morrison and Boyd
    5. Heterocyclic Chemistry by T.L. Gilchrist

    Unit-I

    Optical Isomerism

     

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